Simeone and Machilone of Spoleto,The Virgin Enthroned

1270-75
Tempera on wood, 32⅙ x 47¼ (79.2 x 120 cm.)
Museum Mayer van den Bergh, Antwerp

The birth of Mary, in the upper left quadrant, is echoed by the birth of Jesus in the lower right, the two being distinguished by their locales -- Mary being born in an environment of built structures, Jesus in a cave.

More of Mary's birth, youth, and marriage
More of the Annunciation (lower left)
More of the Assumption (upper right)

Source: Web Gallery of Art