Pinturicchio (Bernardino di Betto)
Adoration of the Christ Child

Fresco? (My site notes say fresco, Web Gallery of Art says wood.)
Basilica of Santa Maria del Popolo, Rome

In the left foreground is St. Jerome, his lion behind him.

More of the Nativity

Photographed at the basilica by Richard Stracke, shared under Attribution-NonCommercial-ShareAlike license.