Joseph Heintz, The Miracle of the Mule
First half of the 17th century
Oil on canvas
Basilica dei Santi Giovanni e Paolo, Venice
This is a miracle attributed to St. Anthony of Padua, who stands in the center with the eucharistic host before the kneeling mule, demonstrating the truth of the doctrine of transubstantiation.
Read more about images of St. Anthony of Padua.
Source: this page at Wikimedia Commons.