Isaac is seen most often in "Abraham and Isaac" images taken from Genesis 22. For these, see my page on Abraham. Also popular in medieval art is the ruse by which Jacob gained the blessing of his father Isaac, discussed in my page on Jacob.
The ruse was devised by Isaac's wife Rebecca, who was chosen for him by Abraham's steward Eliezer. This episode is pictured in a few images such as this one:
Prepared in 2019 by Richard Stracke, Emeritus Professor of English, Augusta University.