Pinturicchio (Bernardino di Betto)
Adoration of the Christ Child

1488-90
Fresco? (My site notes say fresco, Web Gallery of Art says wood.)
Basilica of Santa Maria del Popolo, Rome

In the left foreground is St. Jerome, his lion behind him.

Read more about the Nativity.

Photographed at the basilica by Richard Stracke, shared under Attribution-NonCommercial-ShareAlike license.